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German J Psychiatry 2001; 4: S3 Anxieties of patients with an automatic implantable cardioverter defibrillator (AICD) -

starting results in frame of an examination via longitudinal section

A. Grzbiela, W. Dengler, V. Kuhlkamp, P. Pau- li, G. Wiedemann

University Tübingen, Dept. of Psychiatry and Psychothe- rapy, Tübingen, Germany University Würzburg, Psychology I, Würzburg, Germany

Purpose of the investigation is to ascertain how anxiety- values of patients compare to average anxiety-values. For that reason, we examinated patients immediately before the implantation. As investigation-instruments questionaires (ACQ, BSQ, MI, FQ, STAI-STAI-Trait, BDI, Hama, BAI, ASI), an interview, expecially developed for this purpose and SKID have been used. Results are

still pending. Possible results might be:

1. no,

The anxiety-value of a defi-patient is respectively only minimal difference

low and shows to the average

value.

Anxiety-values are significantly higher than

the avera-

The patient shows anxieties, dominantly

based on

2. ge. 3.

the cardiac disease or anxiety disorder.

The interview represents the first step of the longitudinal examination. After T1 (3 Months after the implantation) and T2 (1 year after the implantation) we are going to find out, whether anxieties increase and which factors are to be made responsible for this increase.

German J Psychiatry 2001; 4: S3 C-type natriuretic peptide augments the anxio- genic action of cholecystokinin tetrapeptide in man

M. Kellner, A. Yassouridis, Y Hua, M. Wendrich, H. Jahn, K. Wiedemann University Hospital Hamburg-Eppendorf, Dept. of Psy- chiatry and Psychotherapy, Hamburg, Germany

The B-type natriuretic peptide receptor agonist C-type natriuretic peptide (CNP) exerts an anxiogenic effect in rodents [1]. We investigated the action of CNP upon experimentally provoked panic attacks in humans using cholecystokinin tetrapeptide (CCK-4). – Twenty healthy male volunteers were pretreated with an intravenous

a double-blind, randomized and balanced design. At

Provoked panic, anxiety and acute dissociative symptoms were measured by different psychometric scales before

and after CCK-4. – CNP pretreatment significantly inc- reased visual analogue scale ratings for „anxiety“ and Acute Dissociation Inventory scores (univariate F-tests p<0,05), while no effect upon panic symptoms was obser- ved. – Our preliminary data support a role of B-type natriuretic peptide receptors in anxiety modulation in normal man. The anxiogenic effects of CNP observed are in contrast to antipanic effects of atrial natriretic peptide (ANP), another member of the family of natriuretic pep- tides that predominantly occupies the A-type natriuretic peptide receptor subtype [2]. The pharmacotherapeutic potential of A-type agonists and B-type antagonists needs further research.

References

1.

Jahn

H,

Montkowsi

A,

Knaudt

K.

Ströhle

A,

Kiefer

F, Schick M, Wiedemann K (2001) Brain Res 893: 21-28

2.

Wiedemann

K,

Jahn

H,

Yassouridis

A,

Kellner

M

(2001) Arch Gen Psychiatry 58: 371-377. – This study was

supported by a DFG grant (Ke 595/4-1).

German J Psychiatry 2001; 4: S3 Maternal Psychosocial Distress after Birth of a Very-Low-Birth-Weight Infant

Kersting A MD, Reutemann M PhD, Schütt K MD, Wes- selmann U MD, Hörnig-Franz I MD, Louwen F MD, Arolt V MD University Münster, Department of Psychiatry and Psy- chotherapie

The birth of an infant with very low birth weight is a critical life event for which parents are usually not prepa- red. The life threatening immaturity and its consequences for the child’s development are traumatic stressors with which mothers have to cope. The aim of this study was to measure the traumatic symptoms of mothers who gave birth to a very-low-birth-weight infant. In a prospective longitudinal study 21 mothers whose infants were born before the 32nd gestational week and/or had a birth weight of less than 1500g were recrui- ted. The control group comprised 39 mothers who had a normal, uncomplicated delivery. The traumatic experien- ce, depression and anxiety were assessed 2-3 days, 14 days, 6 months and 14 months postpartum. Preliminary results 2-3 and 14 days after birth show that mothers of preterm babies have to cope with higher levels of traumatic distress, depression and anxiety than mothers of mature babies. The results 6 and 14 months postpartum will reveal whether the traumatic experiences lead to posttraumatic stress disorder according to DSM-IV in some mothers.

S3

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