Chemical agents that damage the cell membrane . Surface active agents . Phenols . Organic solvents
Chemical agents that denature proteins . Acids and alkalies
Chemical agents that modify functional groups of proteins and nucleic acids
. Heavy metals . Oxidizing agents . Dyes . Alkylating agents
1. Chemical agents that damage the cell membrane
Surface active agents a. Cationic agents .Quaternary ammonium compounds (Quates) It causes loss of cell membrane semi permeability leading to loss of nutrients and essential metabolites. It as well denatures protein.
More active in Gram-positive bacteria than in Gram-
More active at alkaline PH