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  • 3.

    Control of diseases of silk worms

  • 4.

    Development of vaccines against anthrax and rabies.

  • 5.

    Discovery of streptococci

The germ theory of disease The complete establishment of the germ theory of disease depended on the work of a German scientist, Robert Koch (1843- 1910).

Major achievements of Robert Koch

1. 2. 3. 4 .

Discovery and use of solid medium in bacteriology Discovery of causative agents of tuberculosis and cholera. Koch’s phenomenon Koch’s postulates

Koch s postulates: proof of germ theory of disease A micro-organism can be accepted as a causative agent of an infectious disease only if the following conditions are satisfied.

  • 1.

    The micro-organism should be found in every case of the disease and under conditions which explain the pathological changes and clinical features.

  • 2.

    It should be possible to isolate the causative agent in pure culture from the lesion.

  • 3.

    When such pure culture is inoculated into appropriate laboratory animal, the lesion of the disease should be reproduced.

  • 4.

    It should be possible to reisolate the bacterium in pure culture from the lesion produced in the experimental animal.

  • 5.

    Now a days additional postulate is mentioned i.e.

4

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