Major agent of bioterrorism and biological warfare
Major pathogen of domesic herbivores that come in contact
organism to evade phagocytosis
Polysaccharide somatic antigen
Protein somatic antigen
Anthrax toxin- Protein toxin: Complex of 3 protein factors Edema factor + Protective antigen = Edema toxin Lethal factor + Protective antigen = Lehtal toxin
Pathogenesis and Clinical feature: Acquired by the entry of spores through injured skin incutaneous anthrax, or mucus membrane in intestinal anthrax, or inhalation of spores in the lung while handling skin and hides
There are four forms of anthrax. 1. Cutaneous anthrax (Malignant pustule): 95 % of anthrax presentation Characterized by a black necrotic lesion with a definite edematous margin onhands, arms, face or neck with regional lymphadenitis associated systemic symptoms. Pulmonary anthrax (Wool sorter’s disease):5% anthrax presntation of 2.