There are seven serotypes(A-G) of which A,B and
E are the principal causes of human illness.
Pathogenesis and Clinical manifestation:
Food botulism . IP = 18-24 hrs . Route of entry is under cooked consumption of C. botulinum toxin contaminated spiced, smoked, vaccum- packed or canned food .The toxin is absorbed from the gut and acts by blocking the release of acetylcholine at synapses and neuromuscular junction and manifests with flaccid paralysis and visual disturbance, inability to swallow, and speech difficulty Death is secondary to respiratory failure or cardiac arrest
botulinum type A or B is usually implicated and affects infants when mixed feeding starts (after fourth month of life). Ingestion and colonisation of the gut with C.botulinum, and production of toxin and adsorption of toxin leads to poor feeding, paralysis (floppy baby), and cranial nerve palsy. Diagnosed by demonstration of the organism or toxin from the stool
3. Wound botulism