. Outer membrane protein
Analogous to por responsible for the meningococcal cellwall
protein of formation
gonococci of por in
20 known serotypes
meningococci. . Lipopolysaccharide Responsible for the toxic effects found in meningococcal disease
Clinical manifestation: . Meningococcal meningitis . Meningococcemia: Meningococcal septicemia
Table 2.5 Comparison features of meningococcal meningitis and meningococcemia
Features . Symptom/sign
Meningococcal meningitis Fever, headache, neck stiffness.
Meningococcemia Fever, petechial rash,
low blood pressure . CSF appearance. . Response to drugs. . % during epidemics.
Cloudy. Satisfactory. 80-90% .
Cloudy or clear Poor 10-20%
Laboratory diagnosis: Specimen: Cerebrospinal fluid, blood Smear: Gram-negative intracellular diplococci