Chronic stage: Generally associated with hypersensitivity manifestations like fever, chest pain, and arthritis . High agglutinin titier Complication: Brucella spondylitis( Vertebral brucellosis) Lab. Diagnosis: Specimen: Blood, Biopsy material (Bone marrow, Lymphnodes), serum Culture: Grow in blood agar, chocolate agar, or brucella agar incubated in 10% CO2 at 35-37 0C for 3 wks Biochemical reaction: Non-hemolytic Catalase positive Oxidase positive Urease test positive Dye inhibition test positive Serology: Agglutination test IgG agglutination titer >1:80 indicate active infection 2.
Doxycycline + rifampin Tetracycline + streptomycin
Prevention and control: Pasteurization of milk and milk products Reduction of occupational hazards Slaughter of all infected animals in dairy herds Vaccination of cattle with live attenuated strin of B.