Developmental cycle of chlamydia The infectious environmental stable particle, named as elementary body is ingested by a host cell. The elementary body is reorganized into reticulate body in the host cell which is specifically adapted for intracellular growth. The reticulate body grows and divides many times to form inclusions in the host cell cytoplasm. With in 24-48 hours of developmental cycle, the reticulate bodies rearrange them selves into infective elementary bodies and released after host cell rupture.
Antigenic structure: Group-specific antigen Species-specific antigen
. Stained with giamsa’s and iodine stain. . Appearance in giemsa’s stain Elementary body -------- Purple Reticulate body---------- Blue Host cell cytoplasm----- Blue . Appearance in iodine stain Brown inclusions in host cell cytoplasm because of glycogen matrix surrounding the particle. . There are 15 serotypes of C. trachomatis.
trachomatis serotype A, B, C causes trachoma.
trachomatis serotype D-K causes genital infection.
trachomatis serotype L1-L3 causes lymphogranuloma