(Integral part of cell wall)
4. Enzymes .Tissue degrading enzymes . Collagenase: Degrade collagen, which is major protein of fibrous connective tissue. . Hyaluronidase: (Early spreading factor) hydrolyzes hyaluronidic acid, which is the ground substance of connective tissue.
. Lecithinase: Splits lecithin phosphorylcholine and glycerides
. Staphylokinase/Streptokinase (fibrinolysin)
Anti-phagocytic factors . Protein A of Staphylococcus aureus . M protein of Streptococcus pyogenes
g. Mycobacterium tuberculosis
Defense mechanisms of the host
Non-specific defense mechanisms
. Many layered impermeable barrier to invasion of the tissues by microorganisms from the environment.