. Perform only one phagocytic event. 2. Macrophages . Produced in the bone marrow and found in blood stream as monocyte and in tissue as fixed macrophage. . Long-lived cells . Can perform many phagocytic events.
Major events in phagocytosis
4. 2. 3. 1. Chemotaxis: Attraction of the phagocytic cell to the site of the organism. Attachment: Adherence of the organism to the membrane of the phagocytic cell. Ingestion of the micro-organism by pseudopods of the phagocytic cells. Formation of phagosome and phagolysosome. Phagosome: The engulfed bacterium by a phagocyte. Phagolysosome: Fusion ofphagosome and lysozyme (bag of hydrolytic and proteolytic enzymes found in phagocytic cells). 5. Intracellular killing of microorganism. 6. Exocytosis (removal) of degraded and killed bacteria. Complement system: Cascade of reactions mediated by
complement components. Complement components are a family of proteins present in serum.
Major functions of complement system