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Infectious Mononucleosis

Synonyms: Pfeiffer’s glandular fever, kissing disease

It predominantly affects adolescents and young adults. The incubation period is 7–9 days.

The patient  may present with fever, pharyngitis, cervical adenopathy, and splenomegaly. Other symptoms include malaise, sore throat, dysphagia and odynophagia. (tonsillitis as the initial or cardinal symptom)

Examination will reveal enlarged tonsils, often with a dirty-gray exudate. The soft palate may be edematous with petechiae.

The blood count initially shows leukopenia, followed later by leukocytosis (20,000/μL) with 80–90% atypical lymphocytes (lymphomonocytoid cells, Pfeiffer cells).

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