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Studies Linking High Ex-Vivo Platelet Reactivity to ADP and Ischemic Events

   Study                                                       Results                                  Clinical Relevance

1.  Barragan et al.

(Catheter Cardiovasc Interv. 2003;59:295)

VASP-P levels

Stent thrombosis

2.  Ajzenberg et al.

(J Am Coll Cardiol. 2005;45:1753)

Shear-induced aggregation

Stent thrombosis

3.  Gurbel et al.

(CREST Study)

(J Am Coll Cardiol. 2005;46:1827)

VASP-P levels

ADP-LTA

Stimulated GP IIb/IIIa expression

Stent thrombosis

4.  Buonamici

(J Am Coll Cardiol. 2007;49:2312)

ADP-LTA

Stent thrombosis

5.  Matzesky et al.

(Circulation. 2005;109:3171)

ADP-LTA

Recurrent cardiac events

6.  Gurbel et al.

(Circulation. 2005;111:1153) (J Am Coll Cardiol;2006;48:2186)

ADP-LTA

Myonecrosis and inflammation

7.  Bliden et al.

(J Am Coll Cardiol. 2007;49:657)

pre-PCI ADP-LTA on chronic clopidogrel

1 year post-PCI events

8.  Cuisset et al.

(J Thromb Haemost. 2006;3:542)

ADP-LTA

30-day post-PCI events

9.  Lev et al.

(J Am Coll Cardiol. 2006;47:27)

ADP and AA-LTA

Post-PCI myonecrosis

10.  Cuisset et al.

(J Am Coll Cardiol. 2006;48:1339)

ADP-LTA

30-day post-PCI events

600 mg – less events

11.  Hochholzer et al.

(J Am Coll Cardiol. 2006;48:1742)

ADP-LTA

30-day MACE

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