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Standard-Dose Clopidogrel

clopidogrel 75-mg daily X 6 months

High-Dose Clopidogrel

clopidogrel 600-mg, then

clopidogrel 150-mg daily X 6 months

Elective or Urgent PCI with DES*

VerifyNow P2Y12 Test 12-24 hours post-PCI

PRU ≥ 230

R

GRAVITAS Study Design

placebo-controlled

Primary Efficacy Endpoint: CV Death, Non-Fatal MI, Stent Thrombosis at 6 mo

Key Safety Endpoint: GUSTO Moderate or Severe Bleeding at 6 mo

Pharmacodynamics: Repeat VerifyNow P2Y12 at 1 and 6 months

All patients received aspirin (81-162mg daily)

*Peri-PCI clopidogrel per protocol-mandated criteria to ensure steady-state at 12-24 hrs

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