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Clopidogrel response status assessed with Multi-plate point-of-care analysis (MEA) and the incidence and timing of stent thrombosis over six months following coronary stenting.

6 Month followup data from Sibbing D et al, J Am Coll Cardiol. 2009 Mar 10;53(10):849-56.

Cumulative incidence of definite ST within six months was significantly higher in low responders [2.5% vs. 0.4%; OR 6.5; 95% CI, 2.4-17.0; P<0.001].

The combined incidence of definite or probable ST was higher as well in low vs. normal responders [4.1% vs. 0.7%; OR 5.8; 95% CI, 2.8-12.3; P<0.0001].

A significant inverse correlation of MEA values and the timing of definite or probable ST (in days) was observed (Spearman coefficient = -0.45; P=0.04)

CONCLUSION

MEA measurements are highly predictive for the occurrence of ST during the first six months following coronary stenting.

In the majority of clopidogrel low responders suffering ST, the ischemic event occurs early in the course after the procedure.

Sibbing D, , et al Thromb Haemost. 2010 Jan;103(1):151-9.

Epub 2009 Oct 26.

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