Clopidogrel response status assessed with Multi-plate point-of-care analysis (MEA) and the incidence and timing of stent thrombosis over six months following coronary stenting.
Cumulative incidence of definite ST within six months was significantly higher in low responders [2.5% vs. 0.4%; OR 6.5; 95% CI, 2.4-17.0; P<0.001].
The combined incidence of definite or probable ST was higher as well in low vs. normal responders [4.1% vs. 0.7%; OR 5.8; 95% CI, 2.8-12.3; P<0.0001].
A significant inverse correlation of MEA values and the timing of definite or probable ST (in days) was observed (Spearman coefficient = -0.45; P=0.04)
MEA measurements are highly predictive for the occurrence of ST during the first six months following coronary stenting.
In the majority of clopidogrel low responders suffering ST, the ischemic event occurs early in the course after the procedure.
Epub 2009 Oct 26.