X hits on this document

136 views

0 shares

0 downloads

0 comments

48 / 57

~30%

75mg/day for 30days Post-PCI

~30%-40% 75mg/day for 5-7days volunteers

~30%-40% 300 mg load Post-PCI

~30%-50% 600 mg load Post-PCI

~1.4x   150mg/d vs. 75mg/d for 30days Post-PCI3

Inhibition of Platelet Aggregation (Wide Response Variability)1

Mechanism of Clopidogrel Response Variability

Clopidogrel Bisulfate

Inactive Carboxylic Acid Metabolite

CYP3A4

CYP3A5

CYP2C19

Active Thiol Metabolite

P2Y12 Receptor

Limited absorption capacity with ceiling effect at 600mg loading dose

Hepatic P450

Cytochromes

lipophilic statins

Genetic polymorphisms

Genetic polymorphisms

Multistep Conversion

15%

Esterases 85%

1. Gurbel PA et al. Thromb Res. 2007;120:311-21. 2.  Taubert et al. Clin Pharmacol. 2006;80:486-501. 3. von Beckerth et al. Eur Heart J.2007;28:1814-9.

P-glycoprotein

(MDR1 3435T genotype)2

?

Smoking, proton pump inhibitors

CYP1A2

CYP2B6, 2C19

Intestinal Absorption

Document info
Document views136
Page views136
Page last viewedSat Dec 03 16:25:33 UTC 2016
Pages57
Paragraphs810
Words3494

Comments