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Central Role of Platelets and Interaction With Coagulation in the Genesis of Thrombosis

Shear, PCI

Plaque Rupture

Initial Activation

Thrombin

Tissue Factor

Collagen

vWF

TxA2

ADP

PAR-1

P2Y12

TP

Activation

Granule Secretion

Amplification

Amplification

Amplification

COX-1

Adapted from Gurbel PA et al. J Am Coll Cardiol. 2007;50:1822-1834.

X

X

X

X

Platelet Aggregation

GPIIb/IIIa Activation

Fibrinogen

Fibrin

+

Platelet -Fibrin

Clot Formation

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