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Biocompatibility Assessment of Edwards Vantex Central Venous Catheter with Oligon Material vs. Chlorhexidine and Silver Sulfadiazine (Antiseptic) Coated Central Venous Catheter

Vantex CVC Whitepaper 03 Vantex CVC vs. Antiseptic CVC

Written by:

Jeffrey M. Lohre, M.A. Edwards Lifesciences LLC

John W. Sagartz, D.V.M., Diplomate, A.C.V.P.

Introduction

Central venous catheters (CVC) are integral to the care of critically ill patients. Nosocomial infections associated with CVC’s are a serious medical complication. To address this problem, numerous methods have been developed to modify the surface of catheters to reduce bacterial adherence and biofilm formation. Two such products commercially available today are the Edwards Vantex CVC with Oligon material (with or without heparin coating*) and a chlorhexidine/silver sulfadiazine coated CVC from Arrow International, Inc. (antiseptic-coated CVC).

Body fluids interact with silver and platinum particles in the material, causing a release of silver ions.

The Vantex CVC utilizes an antimicrobial material called Oligon that is extruded from polyurethane combined with natural silver and platinum metals and carbon black. Since the antimicrobial properties are integral to the Oligon material, antimicrobial protection is inherent to both the inner and outer surfaces of the catheter. The antiseptic-coated CVC is comprised of silver sulfadiazine and chlorhexidine, which is only (at the time this test was conducted) applied to the outer surface of the catheter. While both CVC devices have been shown to be efficacious at reducing bacterial growth in limited studies, the potential for allergic or sensitivity response of patients exposed to these catheters has not been thoroughly researched. The aim of this study was to examine the biocompatibility of both of these antimicrobial catheters.

LEGEND

Silver Particle

Platinum Particle

Silver Ion

Electrolyte

Electron

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