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Table of Contents

Section 1.Introduction1

Section 2.Description4

I.Animal Care and Use Programme4

A.Programme Management4

1.Programme Management Responsibility4

a.The Institutional Official4

b.The Designated Veterinarian4

c.Collaborations4

2.Personnel Management4

a.Training and Education5

i.Veterinary and Other Professional Staff5

ii.Animal Care Personnel5

iii.The Research Team5

b.Occupational Health and Safety of Personnel6

i.Hazard Identification and Risk Assessment6

ii.Facilities, Equipment and Monitoring6

iii.Personnel Training7

iv.Personal Hygiene8

v.Animal Experimentation Involving Hazards8

vi.Personal Protection9

vii.Medical Evaluation and Preventive Medicine for Personnel10

c.Investigating and Reporting Animal Welfare Concerns10

B.Programme Oversight11

1.The Role of the IACUC/OB11

a.IACUC/OB Composition and Function11

b.Protocol Review11

c.Special Considerations for IACUC/OB Review12

i.Experimental and Humane Endpoints12

ii.Unexpected Outcomes that Affect Animal Well-being12

iii.Physical Restraint12

iv.Multiple Survival Surgical Procedures13

v.Food and Fluid Regulation13

vi.Use of Non-Pharmaceutical-Grade Drugs and Other Substances13

vii.Field Investigations14

viii.Agricultural Animals14

ix.Animal Reuse14

2.Post-Approval Monitoring14

II.Animal Environment, Housing and Management15

A.Animal Environment15

1.Temperature and Humidity15

2.Ventilation and Air Quality15

3.Life Support Systems for Aquatic Species16

4.Noise and Vibration16

B.Animal Housing (All terrestrial, flighted, and aquatic species)16

1.Primary Enclosures16

2.Environmental Enrichment, Social and Behavioural Management17

a.Enrichment17

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