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Parkinsonism is a disease of the “extrapyramidal motor system”.

Question: What is pyramidal motor pathway? _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

II. Etiology (causes) Natural causes of Parkinson’s disease are not known - but some clues about its etiology are:

  • -

    it’s onset usually occurs later in life - first symptoms appear in

a p p r o x i m a t e l y _ _ _ _ _

of individuals between the ages of

________

.

  • -

    approximately 1% of people over 60 have Parkinson’s disease.

  • -

    it is a ___________ illness - usually begins with benign symptoms

(tremors) before it produces serious motor dysfunctions.

- many observed in the presentation of ________________________ initial symptoms, progression of disease, and response to pharmacological treatment.

  • -

    in 1997, a group of scientist at NIH claimed the discovery of an

abnormal gene that is linked to the development of Parkinson’s

disease, but

.

_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

  • -

    some observed links with environmental (chemical) pollution - but incidence has not really changed since beginning of industrial revolution, when human-made harmful chemicals were in low abundance.

Note: the syndrome can be caused by certain drug treatment (MPTP), (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). 2

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