Specific neural defects associated with Parkinson’s disease:
Determined by a series of important findings:
Animal studies by Swedish scientists in the 1950’s
large concentration of ____________ in striatum.
treatment of laboratory animals with _________ (a tranquilizer) depletes brain DA and produces ______________ similar to those of Parkinson’s patients.
________could normalize (even reverse) the deficits in reserpine- treated animals.
Post-mortem studies on human brains in 1960
large decrease in DA content of brain of Parkinson’s patients
compared to ____________________ b. high correlation between the . and the _____________________ magnitude of DA depletion. c. accumulation of __________ (aggregates of cytoskeletal proteins) within the cytoplasm of substantia nigra neurons (dying cells??).
these cells are the
_____________________________________ source of DA and their destruction results in decreased DA release at their target (striatum).