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Specific neural defects associated with Parkinson’s disease:

Determined by a series of important findings:

  • 1.

    Animal studies by Swedish scientists in the 1950’s

    • a.

      large concentration of ____________ in striatum.

    • b.

      treatment of laboratory animals with _________ (a tranquilizer) depletes brain DA and produces ______________ similar to those of Parkinson’s patients.

    • c.

      ________could normalize (even reverse) the deficits in reserpine- treated animals.

  • 2.

    Post-mortem studies on human brains in 1960

    • a.

      large decrease in DA content of brain of Parkinson’s patients

compared to ____________________ b. high correlation between the . and the _____________________ magnitude of DA depletion. c. accumulation of __________ (aggregates of cytoskeletal proteins) within the cytoplasm of substantia nigra neurons (dying cells??).

d.

  • -

    these cells are the

_____________________________________ source of DA and their destruction results in decreased DA release at their target (striatum).

Substantia nigra

6

Control

Parkinson’s patient

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