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Treatment of Parkinson’s disease

S p e c i f i c d e f e c t i s : _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

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Treatments: Overall strategy is:

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A. Specific drug therapies, effectiveness, and short-comings:

1. Give dopamine (DA): not effective - .

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________ 2. Give DA precursor (L-DOPA): effective in improving and even

relieving symptoms. - ______________________________ - produces some (nausea, confusion, _____________________ involuntary movements). 3. Give L-DOPA and carbidopa: can be more effective than L-DOPA alone in relieving symptoms. - has similar side-effects as with L-DOPA alone. 4. Give D2 receptor agonist with L-DOPA: can have increased effectiveness compared to L-DOPA alone, especially in the more

advanced stages of the disease. - c a n p r o d u c e _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ . _ _ _

______________________________________

  • 5.

    Give DA re-uptake blocker: may be effective initially, but will loose effectiveness at more advanced stages of disease when too many substantia nigra neurons are dead.

    • -

      because it increases overall dopamine activity at all dopaminergic synapses, these produce a range of side-effects.

  • 6.

    Give a drug that blocks DA degradation: effectiveness and side- effects similar to DA re-uptake blockers.

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