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DL-LACTONE CAS N°:79-50-5 - page 108 / 113

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OECD SIDS 5. TOXICITY

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

the study in the case of the females, while the males were killed after 28 days so that potential recovery could not be assessed. Reproductive, breeding and developmental parameters were unaffected up to 1000 mg/kg bw/d. Based on the results in this combined repeated dose toxicity

study with reproduction/developmental screening test, definitive suc-chronic parental NOAEL was established

200 mg/kg bw/d. The definitive reproductive,

breeding

the as being and

developmental NOAEL was established as being 1000 mg/kg bw/d.

Reliability:

(1)

valid without restriction

Flag: 15-MAR-2005

OECD test under GLP. Critical study for SIDS

endpoint

(5)

      • 5.8.3

        Toxicity to Reproduction, Other Studies

    • 5.9

      Specific Investigations

    • 5.10

      Exposure Experience

5.11 Additional Remarks

Type:

Result:

Reliability:

11-MAR-2005

interactions

ile on Pantola DL-, D- or un against the e agents". Spec or inability t s exposed to u

ctone states, "Numerous defined pantolactone can ffects (often genotoxic) ifically, dl-lactone o divide normally in ltraviolet radiation or

tions orts in peer-r s regarding an capabilities o t 2.

eviewed literature, all timutagenic respectively f (dl-)lactone, hence

Biochemical or cellular

(52)

(56)

(65)

(42)

(29)

(30)

(37)

The BIBRA Toxicity Prof

studies have shown that protect micro-organisms of certain chemicals or restituted the ability Escherichia coli mutant thermal treatment.

(2)

valid

with

restric

Several

independent

rep

with

similar

conclusion

(1) (4) (11)

(19)

mutagenicity-reversing

reliability

estimated

a

108

UNEP PUBLICATIONS

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