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DL-LACTONE CAS N°:79-50-5 - page 22 / 113

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OECD SIDS 1. GENERAL INFORMATION

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

Classified:

no classification required (no dangerous properties)

Remark:

based on available physico-chemical, toxicological and environmentally relevant substance data

16-AUG-2004

(41)

1.6.3 Packaging

1.7 Use Pattern

Type: Category:

industrial Chemical industry: used in synthesis

21-JUL-1998

1.7.1 Detailed Use Pattern

Industry category:

3

Chemical industry: chemicals

used

in

Use category: Extra details on use category:

Emission scenario document:

synthesis 15 Cosmetics No extra details No extra details not available

necessary necessary

Processing:

no

16-AUG-2004

Industry category:

3

Chemical industry: chemicals

used

in

Use category: Extra details on use category:

Emission scenario document:

synthesis 41 Pharmaceuticals No extra details necessary No extra details necessary not available

16-AUG-2004

1.7.2 Methods of Manufacture

Orig.

of

Subst.:

Synthesis

Type:

Production

Method:

Isobutyraldehyde is reacted with formaldehyde in the presence of a catalyst to produce an aldol (the catalyst is recovered

and parti cyanohydr produced acid unde the react reaction. acid to p aqueous r DCM/DL-la isolate c

ally recycled). The aldol is then converted to a in by reacting it with hydrogen cyanide, which is in situ by reacting sodium cyanide with sulphuric r pH control. Any cyanides remaining at the end of ion are removed by boiling and nitrogen purging the

The cyanohydrin is reacted with excess sulphuric roduce DL-lactone, which is extracted from the eaction mixture into dichloromethane (DCM). The ctone mixture is distilled to recover the DCM and rude DL-lactone.

22

UNEP PUBLICATIONS

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