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DL-LACTONE CAS N°:79-50-5 - page 25 / 113

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OECD SIDS 1. GENERAL INFORMATION

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

a maximum of 0.4% of the total estimated to be lost to aqueou on-site sewage works and a max produced DL-lactone was estima distillation residues which ar CEMfuel; losses to the atmosph due to the closed production s

produced DL-lactone was s effluent treated in the imum of 0.75% of the total ted to be lost with the e used (incinerated) as ere were estimated to be 0%, ystem.

Reliability:

(2)

valid with restrictions

Communication

from

production

site production manager.

05-JAN-2006

(45)

Source of exposure: Human: exposure by production

Exposure to the:

Substance

Result:

DSM Nutritional Products Dalry has conducted a risk

Reliability:

assessmen COSHH (Co accordanc of the CO productio DL-lacton this inte found. Exposure process s operation at sampli exposure water at potential water at potential (2) vali Communica

t programme for all chemicals on its site, called ntrol of Substances Hazardous to Health) in e with the applicable UK legislation. The results SHH assessment programme for the DL-lactone n process indicate that occupational exposure to e is very low, due to the semi-liquid nature of rmediate and the closed system in which it is to be

to DL-lactone mainly occurs through completion of ampling and potentially during drumming-off s. The in-process sampling schedule for DL-lactone ng port A is 6 samples per month with a potential duration of 1 minute/sample, for DL-lactone 90% in sampling port B is 1 sample per day with a

exposure of 1 minute/day and for DL-lactone 90% in sampling port C is 1 sample per day with a

exposure of 1 minute/day. d with restrictions tion from production site production manager.

13-JUN-2005

(45)

1.11 Additional Remarks

Memo:

Natural occurrence and formation?

Result:

The Merck Index (1996) describes Pantolactone as a

"degradation product of pantothenic acid from liver: Williams, Major, Science 91, 246 (1940)". Based on this statement, the TNO (1995) Toxicity Profile on Pantolactone states that "Pantolactone [presumably the D- form] is a degradation product of D-pantothenic acid. The latter is a member of the B-complex vitamins and occurs widely in animal and plant tissue, the animal liver being the richest common source (Merck 1989)". Both statements are clear but not quite unambiguous. The tempting conclusion that Pantolactone, either D- or L- or dl-lactone, is a natural degradation product that is present in the liver, is not substantiated by the original source. Both Williams and Major (1940) and Wolley et al. (1939) did not find Pantolactone in the liver but degraded a substance from liver extracts that was later identified as pantothenic acid; one cleavage product was beta-alanine, the other was identified as a hydroxy acid (later shown to correspond to pantoic acid), which "easily forms a lactone" (Wolley et al,

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