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DL-LACTONE CAS N°:79-50-5 - page 54 / 113

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OECD SIDS 3. ENVIRONMENTAL FATE AND PATHWAYS

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

safety data sheets.

30-JUN-2005

(3)

Type: Inoculum:

aerobic other: activated sludge, mixed domestic and industrial,

Concentration: Contact time: Degradation: Result: Kinetic:

Control Subst.: Deg. product:

non-adapted 30 mg/l related to DOC 21 day(s) = 97 % after 21 day(s)

inherently biodegradable

5 day(s) 7 day(s) 14 day(s) 21 day(s) other: none not measured

= 34 % = 47 % = 90 % = 97 %

(Dissolved Organic Carbon)

Method:

Year: GLP: Test substance:

other: Zahn-Wellens Test, corresponding to OECD guideline 302 B 1985 no other TS

In order to characterise the aqueous phase of the dl-lactone step in sythesis, a Zahn-Wellens test with combined samples from lab batches was performed in the in-house wastewater lab. The standadised in-house Zahn-Wellens test for inherent biodegradability was run as follows (not explicitly described in the reference, but standard lab procedure). Activated sludge sources were a small municipal sewage works at Therwil (Switzerland, near Basle), serving approximately 5000 inhabitants and having no chemical or pharmaceutical industry input, and activated sludge from the Roche in-house pilot sewage treatment plant, which is continuously fed a flow-proportional sample of the actual Roche chemical effluent to the industrial wastewater treatment plant in Basle. Sludge samples were rinsed, mixed in equal proportions and standardised to 100 mg sludge (dry mass)/l. The concentrated composite extract was diluted at 9 ml/l with the 100 mg/l activated sludge, resulting in 130 mg DOC/l. 2-l batches were set up in large Erlenmeyer flasks and stood on a magnetic stirrer. The vessels were continuously aerated and kept at room temperature in the lab (generally not in the dark). Samples were taken at indicated intervals, filtered and DOC-analysed. Percentage of elimination (biodegradation combined with adsorption) was expressed as residual DOC at time t divided by initial DOC at time 0. While the whole extract was certainly not readily biodegradable (BOD5 = 0, see methods), a diluted extract at 130 mg DOC/l was well biodegradable in this Zahn-Wellens test, achieving 90% elimination as measured by DOC in 14 days and 97% in 21 days. Test substance was a composite sample of aqueous extraction phases from laboratory batches of the dl-lactone production step. This was characterised by summary parameters as follows:

Acid value (pH 7)

6460 mval/l

COD BOD5 TOC

40000 mg O2/l 0 mg O2/l 14000 mg C/l

Method:

Result:

Test substance:

54

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