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DL-LACTONE CAS N°:79-50-5 - page 68 / 113

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OECD SIDS

DL-LACTONE

5. TOXICITY

ID: 79-50-5

DATE: 18.01.2006

5.0 Toxicokinetics, Metabolism and Distribution

5.1 Acute Toxicity

Type:

LD50

Species:

rat

Strain:

other: Roche inbred strain

Sex:

no data

Vehicle:

no data

Doses:

no data

Value:

= 9700 mg/kg bw

5.1.1 Acute Oral

Toxicity

Method:

Year: GLP: Test substance:

other: Roche gavage oral toxicity test 1976 no as prescribed by 1.1 - 1.4

Method:

As usual for this internal Roche testing scheme, groups of 5 or 10 animals per dosage were used. Administration was by gavage. Observation was 10 days after administration, then the test animals were killed and dissected. Statistics were computed if applicable. Controls were historical with the same

Result:

rat strains. Lethal dose

Time after gavage

24 h

10 d

LD10, mg/kg

6200

6200

LD50, mg/kg

9700±1600

9700±1600

LD90, mg/kg

15000

15000

Test substance:

"dl-Lactone (pure)"

, Mag-No 4 3576 1, no information on actual

Conclusion:

percentage. Pure dl-lactone has a low oral toxicity to rats with an LD50 of 9700 mg/kg bw; there is a comparatively wide range between LD10 and LD90 of 6200-15000 mg/kg bw. Moreover, the lethal doses being the same at 24 hours and 10 days, pure dl-lactone

Reliability:

exerts its (2) valid While this

low toxicity rapidly, with restrictions test is reported only

within the first 24

hours.

in very abbreviated

form,

the acute performed

toxicity group led by the author of large series of highly standardised

the report toxicity tests

in the late 1960s, dedicated facility

1970s and early 1980s. Serial testing in a assures dependably regular animal keeping,

Flag: 25-AUG-2004

test substance administration, laboratory protocol and reporting. Therefore these internal data are regarded as and dependable. Critical study for SIDS endpoint

valid

(12)

Type:

LD50

Species:

mouse

Strain:

other: Roche inbred strain

Sex:

no data

Vehicle:

no data

Doses:

no data

68

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