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DL-LACTONE CAS N°:79-50-5 - page 7 / 113

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OECD SIDS

DL-LACTONE

1.3

Physico-Chemical properties

Value Solid (powder) 78ºC 247ºC 1.17 g/cm3

Reference Conduit, 2002 F. Hoffmann-La Roche F. Hoffmann-La Roche F. Hoffmann-La Roche

0.7038 hPa (60ºC) 0.0844 hPa (25ºC)

F. Hoffmann-La Roche Calculation, Uses 4.02, 2004

Table 1

Summary of physico-chemical properties

Property Physical state Melting point Boiling point Density (20ºC) Vapour pressure

Water solubility

>500 g/L -0.69

F. Hoffmann-La Roche OECD 107, Willems, 1999

Partition coefficient n-octanol/water (log value)

Henry’s law constant

<0.0001 atm.m3/mol

Calculation, Uses 4.02, 2004; EPISuite 3.11, 2003; SPARC

Partition coefficient organic carbon/water

<10

Calculation, Uses 4.02, 2004; EPISuite 3.11, 2003;

Partition coefficient in activated sludge/water

Ca. 220 l/kg

Desmares-Koopmans, 2004

Auto ignition temperature Flash point Explosive properties

Ca.400ºC 122ºC

Schildknecht, 1981 Schildknecht, 1981 F. Hoffmann-La Roche

At 500ºC moderate dust explosion hazard

pKa (acidic group)

13.1

Calculation, Willems, 1999; SciFinder, 2004; SPARC

2

GENERAL INFORMATION ON EXPOSURE

DL-Lactone is used in the synthesis of cosmetics and pharmaceuticals. It is an intermediate in the production of Calcium D-Pantothenates. A small amount (0.17-0.53%) is isolated and sold to a third

party.

2.1

Production Volumes and Use Pattern

The yearly production volume of worldwide (see IUCLID, 2004) with

DL-lactone is estimated by a slightly decreasing tendency.

industry

at

1000-5000

tonnes

In the Nordic Countries (Norway Sweden and Denmark) no use of DL-lactone was identified (SPIN database 12-05-05).

DL-lactone is not listed in the Swiss Toxic Products Register (Giftliste online database, 13-JUN- 2005).

UNEP PUBLICATIONS

7

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