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DL-LACTONE CAS N°:79-50-5 - page 70 / 113

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70 / 113

Type:

LD50

Species:

mouse

Strain:

other: Roche inbred strain

Sex:

no data

Vehicle:

no data

Doses:

no data

Value:

= 4000 mg/kg bw

OECD SIDS 5. TOXICITY

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

Result:

Test substance:

Conclusion:

Reliability:

25-AUG-2004

Method:

Year: GLP: Test substance:

Method:

Result:

Test substance:

Conclusion:

Reliability:

70

other: Roche gavage oral toxicity t 1976 no other TS

est

As usual for this internal Roche te or 10 animals per dosage were used. gavage. Observation was 10 days aft test animals were killed and dissec computed if applicable. Controls we mouse strains.

"dl-Lactone (technical)", Mag-No 4 actual percentage. Technical dl-lactone has a relative mice with an LD50 of 4000 mg/kg bw; LD90 is 2540-6300 mg/kg bw. The let 24 hours and at 10 days, showing th

UNEP PUBLICATIONS

sting scheme, groups of 5

Administration was by er administration, then the ted. Statistics were re historical with the same

0d 540 000±650 300 2175 8, no information on

ly low oral toxicity to

the range between LD10 and hal doses were the same at at technical dl-lactone

the first 24 hours.

very abbreviated form,

er gavage

1

0d 8000 8000 8000 2175 8, no information on

, Mag-No 4

> >

a low oral 0 mg/kg bw. the highes e lethal do al doses be at technica the first

toxicity to rats with an The LD10 was 8000 mg/kg t dose administered, no es can be derived from this ing the same at 24 hours l dl-lactone exerts its low 24 hours, similar to pure

Time after gavage

24 h

1

2540

2

4000±650

4

6300

6

(12)

exerts its (2) valid While this

toxicity rapidly, within with restrictions test is reported only in

"dl-Lactone (technical)" actual percentage. Technical dl-lactone has LD50 of greater than 800 bw; as 8000 mg/kg bw was LD50 or higher-percentil test. Moreover, the leth and 10 days, it seems th toxicity rapidly, within

Lethal dose

LD10, mg/kg LD50, mg/kg LD90, mg/kg

Lethal dose

Time aft

24 h

LD10, mg/kg

8000

LD50, mg/kg

>8000

LD90, mg/kg

>8000

very abbreviated form, author of the report andardised toxicity tests 1980s. Serial testing in a ly regular animal keeping, ratory protocol and

data are regarded as valid

toxicity group

led by the

large series o

f highly st

test

substance

administr

and early es dependab ation, labo se internal

restrict

ions

is repor

ted only in

in the late 1960s, dedicated facility

1970s assur

reporting. Therefore and dependable.

the

dl-lactone. (2) valid with While this test

the acute performed

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