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DL-LACTONE CAS N°:79-50-5 - page 71 / 113

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OECD SIDS 5. TOXICITY

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

the acute toxicity group led by the author of the report performed large series of highly standardised toxicity tests in the late 1960s, 1970s and early 1980s. Serial testing in a dedicated facility assures dependably regular animal keeping, test substance administration, laboratory protocol and reporting. Therefore these internal data are regarded as valid and dependable.

26-AUG-2004

(12)

Type:

Species: Strain: Sex: No. of Animals: Vehicle: Doses: Value:

other: LDlo in range-finder test to micronucleus mutagenicity assay mouse other: NMRI BR male/female 14 physiol. saline 2000 and 1500 mg/kg bw = 2000 mg/kg bw

Method:

Year: GLP: Test substance:

other: OECD Guideline 474 2002 yes as prescribed by 1.1 - 1.4

Method:

Remark:

Result:

Test substance:

A range-fin mice was pe dl-lactone physiologic OECD study protocol. In a range- females dos per kg bw, observation more males first 1.5 h one male ha survivors s females wer saline per lethargy wi and female and had a r survivors s dl-Lactone

ding study for the dose in a micronucleus test in rformed with an administration by gavage of at doses of 2000 and 1500 mg/kg be in 10 ml of al saline; full details are given in chapter 5. under GLP, but not according to an acute toxicity

finder study with mice, out of 4 males and 4

ed with 2000 mg dl-lactone all treated animals showed

in

physiological saline

abnormalities

during

an

period of 3 days; 1 male died within 20 min, 2 and 1 female died within 1.5 hours. During the ours, all animals showed lethargy or convulsions, d tremors. At days 2 and 3 after gavage, all howed no abnormalities. An additional 3 males and

3

e

dosed

with

1500

mg

dl-lactone

in

physiological

kg

bw.

All

treated

animals

except

one

female

showed

thin the first 20 min; after 1.5 hours, 2 one male each showed no signs while thothers were lethargic ough coat. At days 2 and 3 after gavage, all howed no abnormalities. from Roche Dalry, batch no. BX226, purity 99.8%

Conclusion:

according to analytical certificate. dl-Lactone had a lowest lethal dose of 2000 mg/kg bw in a range-finding study; 4/8 animals died within a short time

(1.5

h) after administration. No animal

from

the

1500-mg/kg-bw

Reliability: 16-NOV-2005

group died

(2)

valid

within 3 days. with restrictions

(33)

      • 5.1.2

        Acute Inhalation Toxicity

      • 5.1.3

        Acute Dermal Toxicity

UNEP PUBLICATIONS

71

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