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DL-LACTONE CAS N°:79-50-5 - page 72 / 113

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OECD SIDS 5. TOXICITY

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

Type: Species: Strain: Sex: No. of Animals: Vehicle: Doses:

Value:

other: NOEL cross-read from OECD skin irritation study rabbit New Zealand white male 3 other: moistened with water 0.5 g/animal (body weights >= 1 kg) applied semi-occlusively for 4 hours >= 500 mg/kg bw

Method:

Year: GLP: Test substance:

other: OECD 404 2005 yes as prescribed by 1.1 - 1.4

Result:

In an OECD skin irritation study, 0.5 g ld-Lactone was moistened with little milli-U water and applied during 4 hours

under semi-occlusive covering to the clipped skin of rabbits weighing at least 1 kg. The test report notes that there was

no sign of skin irritation in any animal nor any symptoms

of

Conclusion:

systemic toxicity nor any mortality. Based on a skin irritation study, dl-Lactone has no

high

dermal toxicity.

Reliability:

(2) OECD

valid study

with restrictions under GLP, but endpoint

only

cross-read.

11-MAR-2005

(55)

Type:

LC50

Species:

mouse

Strain:

no data

Sex:

no data

No. of Animals:

3

Vehicle:

no data

Doses:

250, 750, 1000, 1500, 2000 mg/kg bw

Route of admin.:

other: injection

Value:

750 - 1500 mg/kg bw

(1982), Molec Pharmacol 22:

5.1.4 Acute Toxicity, other Routes

Method:

Year: GLP:

Test substance:

as described in Klunk et al. 438-443 1982 no data

as prescribed by 1.1 - 1.4

Method:

Two or three mice per treatment group were injected (not stated whether i.p., i.v. or i.m.) with dl-lactone in undescribed vehicle. Time to first clonic seizure (alternate contraction and relaxation) and/or to first tonic seizure (persistent contractions, usually resulting in death) was recorded and compared with that of other substituted butyrolactones in order to determine potency and mechanism respectively important structural determinants of physiological action. Full details of methods are given in a

previous publication: Klunk 22: 438-443.

WE et al. (1982), Molec Pharmacol

Result:

Mice per group

Dose ____________________

mg/kg

bw

mmol/kg

bw

Time to first seizure of type _____________________________

clonic, s

tonic, s

72

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