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DL-LACTONE CAS N°:79-50-5 - page 73 / 113

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OECD SIDS 5. TOXICITY

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

Type:

LD50

Species:

mouse

Strain:

no data

Sex:

no data

Vehicle:

no data

Doses:

0.06?, 600 mg/kg bw

Route of admin.:

i.p.

Value:

= 600 mg/kg bw

Test substance:

Conclusion:

Reliability:

28-JUN-2005

(31)

Method:

Year: GLP: Test substance:

no details available 1979 no data other TS

Remark:

Result:

Test substance: Conclusion:

UNEP PUBLICATIONS

73

3

1000

7.69

246±135

(3/3)

12

3

1500

11.5

85±10

(3/3)

2

3

2000

15.4

101±28

(3/3)

A huge difference of four magnitude mg/kg) and the LD50 (0.6 g/kg) is n publication is in Russian, it canno gap is correctly cited or whether o translated erroneously, hence, this resolved at present. The TNO (1995) Toxicity Profile on Russian publication (Moiseenok et a "Intraperitoneal LD50 mouse (D-pant (Moiseenok et al. 1979). Intraperitoneal injection of D-pant did not affect the level of 'the ac liver or brain of mice. Earlier wor referred to where such treatment ca reactions and body temperature', an action of other chemicals (Moiseeno D-Pantolactone, CAS 599-04-2, no fu Based on a secondary source, D-lact acute intraperitoneal toxicity with

2

250

1.92

-

(0/2)

-

(0/2)

3

750

5.77

340±131 (3/3)

-

(0/3)

lactone) was s (College

dose-dependent kg bw no effects clonic after a shorter tarted at a dose

both higher the respective reaction time. ) that "a tonic LC0 of 50 mg/kg bw and

cle

ar presentation

s between the NOEL (0.06 oted. As the original t be said whether this wide ne of the units was

75

(1/3)

87±174 (3/3) 39±126 (3/3)

"DL-Pantolactone (alpha-hydroxy-beta,beta-dimethyl-gamma-butyro obtained from Chemical Procurement Laboratorie Point, NY)." No further information given. dl-Lactone administered by injection leads to neurophysiological effects in mice. At 250 mg/ were observed (NOEL). All higher doses caused convulsions with the first seizures appearing delay the higher the dose; tonic convulsions s of 1000 mg/kg bw in one of three animals while doses caused tonic seizures in all animals of treatment groups with a highly dose-dependent Judging from the remark in the paper (page 445 seizure [...] usually resulted in death", the dl-lactone in mice by injection probably was 7

journal,

question cannot be

the LC50 between 750 and 1500 mg/kg bw.

scientific

Pantolactone cites from a l., 1979) as follows: olactone): 0.6 g/kg bw

olactone at 0.06 mg/kg bw etylation coenzyme' in the k [reference not given] is used 'reduced behavioural d potentiated the soporific k et al. 1979)." rther details given. one has a comparatively low

an LD50 of 600 mg/kg bw.

(4)

not assignable

in

Peer-reviewed of results.

paper

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