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DL-LACTONE CAS N°:79-50-5 - page 74 / 113

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OECD SIDS 5. TOXICITY

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

Reliability:

(4)

not assignable

Short citation be judged.

from

a

Russian

publication,

reliability

cannot

22-SEP-2004

(36) (56)

Type:

EC0

Species:

mouse

Strain:

no data

Sex:

no data

Vehicle:

no data

Doses:

250, 750, 1000, 1500, 2000 mg/

Route of admin.:

other: injection

Value:

= 250 mg/kg bw

kg bw

(1982), Molec Pharmacol 22:

Method:

Year: GLP: Test substance:

as described in Klunk et al. 438-443 1982 no data as prescribed by 1.1 - 1.4

Method:

Two or three mice per treatmen stated whether i.p., i.v. or i undescribed vehicle. Time to f contraction and relaxation) an (persistent contractions, usua recorded and compared with tha butyrolactones in order to det respectively important structu physiological action. Full det previous publication: Klunk WE

t group were injected (not .m.) with dl-lactone in irst clonic seizure (alternate d/or to first tonic seizure lly resulting in death) was t of other substituted ermine potency and mechanism ral determinants of ails of methods are given in a

et al. (1982), Molec Pharmacol

22: 438-443.

Result:

Mice per group

Dose ____________________

mg/kg

bw

mmol/kg

bw

Time to first seizure of type _____________________________

clonic, s

tonic, s

-

(0/2)

340±131

(3/3)

246±135

(3/3)

85±10

(3/3)

101±28

(3/3)

2

250

1.92

3

750

5.77

3

1000

7.69

3

1500

11.5

3

2000

15.4

287±174 (3/3) 39±126 (3/3)

-

(0/2)

-

(0/3)

(1/3)

1275

Test substance:

Conclusion:

"DL-Pantolactone (alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone) was obtained from Chemical Procurement Laboratories (College Point, NY)." No further information given. dl-Lactone administered by injection leads to dose-dependent neurophysiological effects in mice. At 250 mg/kg bw no effects were observed (NOEL). All higher doses caused clonic convulsions with the first seizures appearing after a shorter delay the higher the dose; tonic convulsions started at a dose of 1000 mg/kg bw in one of three animals after more than 20 min while both higher doses caused tonic seizures in all animals of the respective treatment groups with a highly dose-dependent reaction time. However, in comparison with five other substituted butyrolactones, dl-lactone was the weakest neurotoxicant, by a factor of five to the next weakest, as measured by the dose in millimoles/kg bodyweight (full data in paper).

Reliability:

(4)

not assignable

Peer-reviewed paper in scientific journal, clear presentation of results.

74

UNEP PUBLICATIONS

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