X hits on this document

PDF document

DL-LACTONE CAS N°:79-50-5 - page 77 / 113

315 views

0 shares

0 downloads

0 comments

77 / 113

OECD SIDS 5. TOXICITY

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

No histopathology was performed.

Result:

Interpretation The results were evaluated according to the OECD Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances (OECD, 1998) and the EC criteria for classification and labelling of dangerous substances and preparations (Council Directive 67/548/EEC and all adaptations to technical progress and amendments of this Directive published in the Official Journal of the European Communities). Irritation No skin irritation was caused by 4 hours exposure to dl-Lactone.

Corrosion There was no evidence of a corrosive effect on the skin.

Colouration/Remnants No staining of the treated skin by the test substance was observed and no test substance remnants were seen.

Test substance:

Conclusion:

Toxicity/Mortality No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred. dl-Lactone from DSM (until 2003 Roche) Dalry, sample no. 06085776, purity 99.6%, dated 24-Sep-2004. Based on the test results and according to the OECD Harmonized

Integrated Hazard Classification System for Human Health and

Reliability:

(1)

valid

without restriction

OECD

study

under GLP.

Environmental Effects of Chemical Substances

dl-Lactone does not have to be classified for skin irritation.

(OECD,

1998),

15-MAR-2005

(55)

Species:

human

GLP: Test substance:

no as prescribed by 1.1 - 1.4

Remark:

May cause irritations after prolonged or intensive contact

Test substance: Reliability:

during occupational handling. As produced/used in synthesis of pantothenic

(2)

valid with restrictions

acid/panthenol.

Occupational

handling

experience,

considered

reliable.

Flag: 16-NOV-2005

Critical

study

for

SIDS

endpoint

(50)

5.2.2 Eye Irritation

Species:

human

Test substance:

as prescribed by 1.1 - 1.4

Remark: Reliability:

May (2)

cause irritations upon direct valid with restrictions

contact

Occupational

handling

experience,

considered

reliable.

16-NOV-2005

(50)

UNEP PUBLICATIONS

77

Document info
Document views315
Page views331
Page last viewedWed Dec 07 14:41:28 UTC 2016
Pages113
Paragraphs4931
Words40344

Comments