OECD SIDS 5. TOXICITY
ID: 79-50-5 DATE: 18.01.2006
No histopathology was performed.
Interpretation The results were evaluated according to the OECD Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances (OECD, 1998) and the EC criteria for classification and labelling of dangerous substances and preparations (Council Directive 67/548/EEC and all adaptations to technical progress and amendments of this Directive published in the Official Journal of the European Communities). Irritation No skin irritation was caused by 4 hours exposure to dl-Lactone.
Corrosion There was no evidence of a corrosive effect on the skin.
Colouration/Remnants No staining of the treated skin by the test substance was observed and no test substance remnants were seen.
Toxicity/Mortality No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred. dl-Lactone from DSM (until 2003 Roche) Dalry, sample no. 06085776, purity 99.6%, dated 24-Sep-2004. Based on the test results and according to the OECD Harmonized
Integrated Hazard Classification System for Human Health and
Environmental Effects of Chemical Substances
dl-Lactone does not have to be classified for skin irritation.
GLP: Test substance:
no as prescribed by 1.1 - 1.4
May cause irritations after prolonged or intensive contact
Test substance: Reliability:
during occupational handling. As produced/used in synthesis of pantothenic
valid with restrictions
5.2.2 Eye Irritation
as prescribed by 1.1 - 1.4
cause irritations upon direct valid with restrictions