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Data Source: Measure 1 a-b — Data needs are listed in the Federal Register. ATSDR fills the data needs through U.S. Environmental Protection Agency regulatory mechanism (test rules), private sector volunteerism, and the direct use of CERCLA funds. Additional data needs are filled through collaboration with the National Toxicology Program (NTP), by ATSDR’s Great Lakes Human Health Effects Research Program, and other agency programs. Also, data needs can be filled through reevaluation of new or existing data (non-ATSDR sponsored) that becomes evident during the toxicological profile update process. Toxicological Profiles that are under development are also listed in the Federal Register along with the release dates. Measure 2 a–b -The Division of Health Studies (DHS) tracks the status of health studies using its internal strategic plan report. Measure 3 – The Division of Health Studies will establish a baseline in FY 2006 for the percent of data needs filled.

Data Validation: Measure 1 a-b — ATSDR’s Division of Toxicology manually monitors and tracks the research being performed to meet the data needs and the numbers of profiles under development and published. The Division reports on its progress towards meeting these targets through quarterly strategic planning reviews with the Office of the Director. Measure 2 a–b - DHS monitors the progress of its health studies through strategic plan reviews that are conducted on a quarterly basis. Measure 3 — DHS will validate the data needs filled on the basis of established criteria and will track and report status during strategic planning reviews.

Cross Reference: Measure 1 — HHS-1, 4, 5, HP-8.12, *-4, PART, 500-3, Measure 2 - HHS-1, 4, HP-8.12, 8.26, 500-3, Measure 3 - HHS-1, 4, HP-8.12, 8.26, 500-3

Goal 2, Performance Measure 1:

ATSDR works to determine the relationship between toxic exposures and disease. ATSDR strives to identify and fill critical data gaps associated with the 275 priority hazardous substances, that is, those substances most often found at NPL sites. For instance, ATSDR has identified a need to determine the effects on the nervous system development in fetuses whose mothers may be exposed to trichloroethylene in their drinking water. ATSDR also prepares and publishes a series of Toxicological Profiles (ToxProfiles). Each profile provides a comprehensive evaluation, summary, and interpretations of available toxicologic and epidemiologic information on a substance.

a) ATSDR fills substance-specific data needs using internal resources within the Division of Toxicology and Environmental Medicine and through university-based research, interagency collaborations, and industry testing. This target reflects the number of data needs filled each fiscal year.

b) This target records the number of final toxicological profiles. As results have been reported for FY 2006, this measure will be retired, and hereafter, will be reflected in ATSDR’s output table.

Goal 2, Performance Measure 2:

ATSDR also works to determine the relationship between toxic exposures and disease through health studies, disease tracking, and surveillance studies. ATSDR’s research findings improve the science base for environmental public health decision-making by filling the gaps in knowledge about effects from exposure to hazardous substances. As results have been reported for FY 2006, this measure will be retired. The measure is being replaced by Performance Measure 3 (below).

a) ATSDR has published a scientific manuscript with results of the Multiple Sclerosis (MS) study conducted in Ohio, Missouri, and Texas documenting regional differences in prevalence of MS.

b) ATSDR continues to evaluate lung disease progression by re-screening persons who had past exposure during packaging and/or processing asbestos-contaminated vermiculite ore mined in Libby, Montana. The University of Cincinnati developed a protocol and received an award from ATSDR to study participants in the Marysville, Ohio area. The University has located the majority of the original 513 cohorts from a study conducted in 1980. ATSDR

released the preliminary results

2005. The manuscript.




of the study’s radiographic findings completed and a final report has

at the been

Annual Thoracic Society meeting in May submitted for publication as a scientific

Goal 2, Performance Measure 3:

This new measure has been developed to communicate more effectively the Agency’s commitment and overall progress towards filling the gaps in knowledge about effects from exposure to hazardous substances. It replaces the

sub-measure regarding number of health studies formerly covered within performance measure two. Division of Health Studies (DHS) fills data needs through site-specific or broader research studies. Data those questions or concerns about exposure to hazardous substances and adverse health outcomes communities, stakeholders, and as identified through DHS’s research agenda.

ATSDR’s needs are posed by



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