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Next slide, please.  Here, I'm just going to give you an idea, a little bit of the averages and the variability.  Interestingly, the variability was lower when we just used the total T4.  In fact, in all studies that I saw there using total T4, the variability was on the order of 10 percent, sometimes a little less, sometimes a little more, but the averages were always very close to 100 percent, and these products are very similar.

Next slide, please.  I just did a little simulation or computation to see what we would expect if we tried to do these studies on lower doses lower than 600 micrograms.  If we are subtracting the baseline and the CV, the coefficient of variation, the variability is due only to the assay, this is the kind of variability that I would expect to see with a 600, 300 and 150 microgram dose because the subtraction of the baseline reduces the values that we see, and if we tried to do, for instance, a 150 microgram study, the variability just due to the assay ‑‑ that's the assay of the active material, nothing to do with biological variation ‑‑ would be at least 44 percent.

Now, there is one slide missing that I

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