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percent or 100 percent have to be dissolved by, I think, 20 minutes or something like that.  In fact, almost all of the generic drugs that are made today are made by a dry granulation in which almost 80 to 100 percent are dissolved within 20 minutes.  Now, this is not true, unfortunately, of the reference product.  The reference product, you can see, is much more slowly dissolved.

May I have the next slide, please?  By the way, levothyroxine is not absorbed in the colon.  It's absorbed only in the small intestine.  It's one of these drugs that we consider to be transit time dependent.  So, if it's transit time dependent, if you look ‑‑ these are some data by Davis that are transit times of the small intestine.  All of these dots represent each individual person in all the studies compiled.  And this is one hour, and you can see that there's only about probably 5 to 10 percent of the people at any give time that have transit times in this particular study of an hour.  It depends on how you do transit times, by the way.  But in this particular study, the transit times were only about an hour.

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