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Therefore, we would expect that with transit times of about an hour and when only 50 percent of the drug may be dissolved in an hour, that there would be a subset that would probably have TSH levels at some point in time, depending upon their transit times.

Now, transit times is a highly variable situation.  For example, if you have a drug that is going to fall over into this area, it would seem to me that you're going to have greater variability in this drug as well, and this greater variability could be seen, for example, in the next slide.

Women.  There are several studies to show that the transit time in women vary within the menses, that the follicular state may be different than other parts.  In fact, this is one study.  There are some controversies about this data because they were used with lactose which is not the best way to measure transit time, but it does illustrate the example.  This is at the follicular phase and this is at the luteal phase at the transit times, almost double the transit times.  So, transit time may be a factor.

The point that I do want to point out is that

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