X hits on this document

Word document

FOOD AND DRUG ADMINISTRATION - page 180 / 263

536 views

0 shares

0 downloads

0 comments

180 / 263

1

of the dosage form on top of that.

Well, that's not the only case.  Our other example that I mentioned is potassium chloride, and how does potassium chloride differ from, say, hormones of the system I just described?  With potassium, on the other hand, the body actually, strictly speaking, doesn't make potassium.  So it more or less shifts it around.  It takes it in from the diet.  It puts it out in the urine and perhaps the feces, and so you're really looking at an equilibrium process where, if a patient is deficient in potassium and is given supplemental potassium, they tend to take more in and store it, hopefully.  But if you deal with normal volunteers with proper and healthy levels of potassium, most of what's taken in is simply put back out again.  So the body doesn't really need to hold onto it or to increase stores.  It basically comes in one end and goes out the other, so to speak.

So the question is, what we do with potassium, on the other hand.  Again, we're dealing with the same set of issues in a way in that there's a lot of potassium already in the blood.  If we give a single dose of potassium, you really don't see that much of a change in

Document info
Document views536
Page views536
Page last viewedSun Dec 04 08:54:47 UTC 2016
Pages263
Paragraphs1551
Words48110

Comments