correction -- or there is an endogenous baseline, one of the characteristics of endogenous substances. And the question is how to best account for that baseline? Does it need to be subtracted from the data that you're measuring? If so, how do you go about doing a proper subtraction or proper baseline correction? You have to really look at a variety of different things, characteristics of the baseline, various methods for correction, you saw some illustrated in previous talks, and what I think is very important is magnitude of baseline in relationship to the total values that you're measuring.
If you really think it through, something with a very, very small baseline in relationship to the total amount after a dose has very little effect on your eventual outcome, and you can go through some calculations to prove this to yourself.
If you look at something, on the other hand, like potassium chloride, where that baseline is a very large percentage of what you're seeing as your signal when you measure it in plasma or blood, actually subtracting that baseline would probably mean that virtually no study