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And Dr. Wartofsky showed the Carr study and had arrows inserted for a 12.5 percent change but really didn't show any data.  It was just kind of if this would happen, then this would happen.

If you look at the Carr study, the original document in 1988, the only relevant comparisons, I think, in terms of changes in TSH with changes in levothyroxine dose are the ones that go from 150 to 175, which is a 17 percent change, and 175 to 200, which is a 14 percent change.  Everything else is 20 percent or greater.

And in that context, I'm trying to move toward the 12.5 percent change and there's no data for that, but there's at least a 17 percent change.  There's only 3 patients out of the supposedly 21 that were in that category that had changes from 150 to 175 or 175 to 200.  The 1 patient that went from 175 to 200, which is a 14 percent change, didn't seem to have much of a change in TSH.  The other three seemed to have some changes.  So that's basically 3 subjects out of 21.

So I wonder how serious the issue is that the Abbott study was not able to detect a 12.5 percent difference.  If that were a 12.5 percent difference in

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