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Science.

DR. VENITZ:  Okay.  Thanks.

The second one may be a more intelligent question.  It relates to the PTI mechanics and that's a question for Dr. Hauck or Dr. Olsson.

I'm working my way through the algorithm, I guess, and it sounds like one of the predefined things that has to happen prior to doing any of this is to agree what those k and f values are.  In other words, that's not something that the sponsor prespecified, but that's something that would be part of a guidance because that defines how your alpha distribution looks like relative to the ideal test.  Is that correct?  Because it sounds like IPAC-RS changed those constants to make the test more amenable.

DR. OLSSON:  Those test coefficients are the essential motor of the test, so to speak.  So what one does is to carefully calculate before what those test coefficients should be in order to give the test the desired characteristics.

So yes, those are predefined and it's a lot of work to calculate them.  We've calculated them for a

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