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Table 1.Evidentiary Basis for Evaluation of Second-Generation

Antipsychotic Drugs

Drug

Reference

Type of study/report

Amisulpride

Sechter et al.,  2002 [65]

RCT, double blind; risperidone

Amisulpride

Leucht at al., 2002 [66]

Meta-analysis

Amisulpride

Colonna et al., 2000 [67]

RCT, open randomized;

Haloperidol comparator

Amisulpride

Mota Neto et al., 1999 [68]

Meta-analysis

Amisulpride

Danion et al.,  1999 [69]

RCT, double-blind;

placebo-controlled

Amisulpride

Peuskens et al., 1999 [70]

RCT, double-blind;

risperidone comparator

Amisulpride

Puech et al., 1998 [71]

RCT, double-blind;

haloperidol comparator

Amisulpride

Wetzel et al., 1998 [72]

RCT, double-blind;

flupenthixol comparator

Amisulpride

Loo et al., 1997 [73]

RCT, double-blind;

placebo controlled

Amisulpride

Speller et al., 1997 [74]

RCT, double-blind;

haloperidol comparator

Amisulpride

Moller et al., 1997 [75]

RCT, double-blind;

haloperidol comparator

Amisulpride

Boyer et al., 1995 [76]

RCT, double-blind;

placebo-controlled

Amisulpride

Paillere-Martinot et al., 1995 [77]

RCT, double-blind;

placebo-controlled

Clozapine

Volavka et al., 2002 [4]

RCT, double-blind; risperidone, olanzapine, haloperidol comparator

Clozapine

Citrome et al., 2001 [5]

RCT, double-blind; risperidone, olanzapine, haloperidol comparator of hostility

Clozapine

Kane et al., 2001 [3]

RCT, double-blind; haloperidol comparator

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