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Considerations for Exposure to Diazinon and Chlorpyrifos - page 10 / 49

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Inhibition of ChE By CPS/CPO

Huff et al. J Pharmacol Exp Therapeutics 269:329-335(1994)

Chlorpyrifos oxon (CPO, the toxic metabolite of chlorpyrifos) inhibits brain cholinesterase at approximately 1000-times the rate of chlorpyrifos (CPS).   This is an important observation in light of the importance of the PON1 polymorphism in detoxifying parent organophosphorothioates (e.g., chlorpyrifos and diazinon) and the oxon contents of residues.

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