Some Concerns About the Parent Organophosphorothioates
For many years, it was thought that the parent organophosphorothioates were quite safe compounds, i.e. they are very poor inhibitors of cholinesterases. However, recent studies reported by Usamani and colleagues at Duke University (see next slide) noted that cytochrome P450 3A4 was inhibited during the bioactivation of parent organophosphorothioate compounds. Since this P450 is an important enzyme in testosterone metabolism, this raises a number of concerns about exposures to the parent compound, particularly questions about consequences of exposure during critical windows of development and affects on reproductive health.