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Considerations for Exposure to Diazinon and Chlorpyrifos - page 13 / 49

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Gene Frequency of PON1 Activity Polymorphism

   Early studies of the genetic variability of serum paraoxonase (PON1) activities in different ethnic groups. Note in the next slide the different allele frequencies of the PON1 activity polymorphism in different populations. In populations of Northern European origin, approximately one-half of the populations were low metabolizers.  Other populations of African or Asian origin had very few low metabolizers (For an excellent review of the early PON1 studies, see Geldmacher v.-Mallinckrodt and Diepgen, Toxicol and Environ Chem 1988; 18:79-196).

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