Why are young individuals more sensitive to OP compounds?
[Cole TB, RL Jampsa, BJ Walter, TL Arndt, RJ Richter, DM Shih, A Tward, AJ Lusis, RM Jack, LG Costa, and CE Furlong. 2003. Expression of human paraoxonase (PON1) during development. Pharmacogenetics 13:357-364 and references cited therein.]
Developmental regulation of plasma PON1 levels is such that newborns have only 1/4th to 1/3rd the levels of plasma PON1 compared with adults.