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Considerations for Exposure to Diazinon and Chlorpyrifos - page 19 / 49

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Why are young individuals more sensitive to OP compounds?

[Cole TB, RL Jampsa, BJ Walter, TL Arndt, RJ Richter, DM Shih, A Tward, AJ Lusis, RM Jack, LG Costa, and CE Furlong. 2003. Expression of human paraoxonase (PON1) during development. Pharmacogenetics 13:357-364 and references cited therein.]

Developmental regulation of plasma PON1 levels is such that newborns have only 1/4th to 1/3rd the levels of plasma PON1 compared with adults.

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