Goals of This Presentation
The purpose of this brief presentation is to share with you what we have learned about human genetic variability in paraoxonase 1 (PON1) and the consequences of this variability with respect to gene/environment interactions, specifically the role of PON1 in protecting against exposure to organophosphorus insecticides, particularly diazinon/diazoxon and chlorpyrifos/chlorpyrifos oxon.
PON1 is a high density lipoprotein (HDL) associated enzyme of 354 amino acids that plays a significant role in the hydrolysis of the highly toxic diazinon metabolite diazoxon. (Also the toxic metabolite of chlorpyrifos, chlorpyrifos oxon).
The presentation also describes the results of experiments carried out in a mouse model. These experiments were designed to provide information on the physiological consequences of the PON1 genetic variability in human populations.