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Considerations for Exposure to Diazinon and Chlorpyrifos - page 21 / 49

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What are the consequences of high PON1 levels?

Early studies on the effects of high PON1 levels on resistance to OP exposure involved the injection of purified rabbit PON1 into mice and challenging the mice with a dermal exposure to OPs.  The early studies were mostly carried out with chlorpyrifos oxon or chlorpyrifos.

To test whether PON1 protects against OP exposure, we first determined the most suitable route of administration of purified rabbit PON1 into mice.  Injection via the iv route was chosen for the experiment on the next slide.  At time zero, purified rabbit PON1 was injected into mice via the tail vein and rates of PON1 hydrolysis of chlorpyrifos oxon (CPOase) and paraoxon (POase) were monitored over time.

(Li et al., J Toxicol and Environ Health 1993; 40:337-346).

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