What are the consequences of low PON1 levels?
The consequences of low levels of plasma PON1 were examined in genetically modified mice that were devoid of liver and plasma PON1.
Drs. Shih and Lusis (UCLA) generated mice devoid of PON1. Mice with only one copy of the PON1 gene have ~50% of the PON1 activity levels (paraoxonase, diazoxonase and chlorpyrifos oxonase). These mice have proven to be invaluable in understanding the physiological role of PON1 in detoxifying specific OP compounds as well as the role of PON1 in protecting against vascular disease.
(Shih DM, Gu L, Xia Y-R, Navab M, Li W-F, Hama S, Castellani LW, Furlong CE, Costa LG, Fogelman AM, Lusis AJ. 1998. Mice lacking serum paraoxonase are also susceptible to organophosphate toxicity and atherosclerosis. Nature 394:284-287)