The Importance of the Mouse Genetic Model
The next slide shows the most surprising result from the series of dermal exposure experiments with the PON1 knockout mice. It was assumed for nearly 50 years that high levels of PON1 would protect against paraoxon toxicity and conversely, low PON1 levels would render individuals sensitive to this OP. As seen in the next slide, we observed no significant differences in paraoxon sensitivity between wild type mice, PON1 hemizygous mice and PON1 knockout mice. The reason for this will become clear in the slide after next.
(Li et al., 2000. Pharmacogenetics, 10:767-779).